1 00:00:03,560 --> 00:00:01,730 the manufacturers of this machine don't 2 00:00:06,019 --> 00:00:03,570 call it that and that the scientific 3 00:00:07,490 --> 00:00:06,029 director of the astute here in the 4 00:00:10,970 --> 00:00:07,500 United States hasn't call it that but 5 00:00:14,509 --> 00:00:10,980 they call it the infra tonic QGM four 6 00:00:16,220 --> 00:00:14,519 point oh and this is listed inside the 7 00:00:18,200 --> 00:00:16,230 fda's of therapeutic massager and the 8 00:00:21,470 --> 00:00:18,210 origins of this the development of this 9 00:00:23,720 --> 00:00:21,480 machine started in China with 10 00:00:24,679 --> 00:00:23,730 experiments I described before where 11 00:00:28,460 --> 00:00:24,689 they were looking at these known 12 00:00:30,169 --> 00:00:28,470 physical these new energies and so the 13 00:00:32,600 --> 00:00:30,179 infrasound that was being emitted by the 14 00:00:34,430 --> 00:00:32,610 china the chinese chicken practitioners 15 00:00:36,229 --> 00:00:34,440 had a particular characteristic that 16 00:00:38,660 --> 00:00:36,239 didn't look like the normal for someone 17 00:00:42,020 --> 00:00:38,670 coming out of humans so they made a 18 00:00:44,479 --> 00:00:42,030 device that basically mimics the 19 00:00:46,940 --> 00:00:44,489 infrasonic emissions coming out of chi 20 00:00:49,910 --> 00:00:46,950 gong practitioner doing external chico 21 00:00:51,819 --> 00:00:49,920 and this device is now commercially 22 00:00:54,080 --> 00:00:51,829 available as i as a therapeutic device 23 00:00:56,270 --> 00:00:54,090 the you know the interesting thing is 24 00:00:59,779 --> 00:00:56,280 that it's has been used mainly for 25 00:01:02,840 --> 00:00:59,789 horses and exit they've actually done 26 00:01:04,820 --> 00:01:02,850 some research on that the equine version 27 00:01:08,179 --> 00:01:04,830 and the human version look quite a bit 28 00:01:10,219 --> 00:01:08,189 alike and they and but they are all 29 00:01:12,710 --> 00:01:10,229 based on the same concept and here's a 30 00:01:15,890 --> 00:01:12,720 transducer head would be emitting 31 00:01:18,800 --> 00:01:15,900 infrasound and it's used quite a bit for 32 00:01:21,590 --> 00:01:18,810 joints based on the work the experience 33 00:01:23,570 --> 00:01:21,600 with horses so let's briefly look at one 34 00:01:26,690 --> 00:01:23,580 of those horse studies with the standard 35 00:01:29,030 --> 00:01:26,700 back horses so they had some functional 36 00:01:30,890 --> 00:01:29,040 data and that was it horses out with 37 00:01:32,359 --> 00:01:30,900 doing your training it would be a lot of 38 00:01:34,310 --> 00:01:32,369 stress the joints they would treat the 39 00:01:37,730 --> 00:01:34,320 joints to basically reduce inflammation 40 00:01:39,920 --> 00:01:37,740 and we accelerate the healing process 41 00:01:42,530 --> 00:01:39,930 and they found functionally that the 42 00:01:46,969 --> 00:01:42,540 horses could run faster and we're very 43 00:01:50,530 --> 00:01:46,979 very pleased with his results some of 44 00:01:53,990 --> 00:01:50,540 the actual experiments were focused on 45 00:01:58,170 --> 00:01:54,000 hyaluronic acid sorry about that very 46 00:01:59,910 --> 00:01:58,180 difficult name of a molecule this is 47 00:02:03,540 --> 00:01:59,920 an important component of extracellular 48 00:02:07,050 --> 00:02:03,550 matrix it's a mediator of inflammation 49 00:02:09,270 --> 00:02:07,060 and so there they've got very clean data 50 00:02:11,160 --> 00:02:09,280 working with horses showing that 51 00:02:14,340 --> 00:02:11,170 influence of this infrasonic generator 52 00:02:18,780 --> 00:02:14,350 to change levels of hyaluronic acid in 53 00:02:21,000 --> 00:02:18,790 the horses so and because it's important 54 00:02:23,490 --> 00:02:21,010 extracellular matrix component this led 55 00:02:27,570 --> 00:02:23,500 us to the hypothesis we want to look at 56 00:02:29,130 --> 00:02:27,580 this in an oncology model we came up 57 00:02:32,160 --> 00:02:29,140 with the idea that it would influence 58 00:02:35,070 --> 00:02:32,170 the membrane dynamics so we had these 59 00:02:36,540 --> 00:02:35,080 two hypotheses first one was that 60 00:02:39,090 --> 00:02:36,550 infrasound is going to increase the 61 00:02:42,240 --> 00:02:39,100 membrane permeability of cancer cells 62 00:02:45,060 --> 00:02:42,250 and that this increased permeability 63 00:02:47,640 --> 00:02:45,070 would allow the chemotherapy to get into 64 00:02:48,930 --> 00:02:47,650 cancer cells more readily and this is 65 00:02:50,820 --> 00:02:48,940 really the definition of chemo 66 00:02:56,490 --> 00:02:50,830 sensitization and allow the chemotherapy 67 00:02:58,140 --> 00:02:56,500 to work better so my laboratory focuses 68 00:02:59,400 --> 00:02:58,150 on brain tumors so this is the model 69 00:03:03,449 --> 00:02:59,410 that we were looking at it specifically 70 00:03:06,360 --> 00:03:03,459 glioblastoma multiforme a orgy p.m. and 71 00:03:09,180 --> 00:03:06,370 so now you can see why din leading up to